As before, I’ll take the corners of each intersection in the clockwise order NE, SE, SW, NW. At each corner I'll describe the 2006 sign(s) of change first, then the 2010 sign(s) of change.
43rd Street
NE — 2006: none; 2010: new awning & sidewalk tables not out (why?)
SE — 2006: none; 2010: scaffolding
SW — 2006: none; 2010: plywood construction fence
NW — 2006: none; 2010: Omni Dry Cleaners now Pet Ark
44th Street
NE — 2006: scaffolding on far right; 2010: scaffolding down
SE — 2006: blue plywood construction fence and vacant lot behind it; 2010: new building finished
SW — 2006: vacant lot on left; 2010: blue sheeting on chain link fence gone
NW — 2006: none; 2010: no change
45th Street
NE — 2006: none; 2010: no change
SE — 2006: street work; 2010: Lali Restaurant front repainted
SW — 2006: none; 2010: "Exit Reality" ad gone from building to the right
NW — 2006: none; 2010: Clinton Grille now Pony Bar, scaffolding up on left
46th Street
NE — 2006: none; 2010: no change
SE — 2006: corner storefront vacant; 2010: Eat Fresh deli new tenant of corner storefront
SW — 2006: none; 2010: no change
NW — 2006: none; 2010: no change
47th Street
NE — 2006: none; 2010: no change
SE — 2006: none; 2010: no change, except Budweiser neon sign in window
SW — 2006: none; 2010: Erik's Barber Shop now Bis.Co. Latte
NW — 2006: none; 2010: new maroon awning next to 5 Brothers (new tenant?), also next to that, Hell's Kitchen replaced D&S
48th Street
NE — 2006: for rent sign on fire escape at left; 2010: new awning on Indian restaurant, Alfa Distribution Corp closed, storefront now vacant, Gourmet deli awning Shortened on 48th street side, black awning replaced red one a little further on
SE — 2006: none; 2010: no change
SW — 2006: none; 2010: no change
NW — 2006: construction fence, big cranes, building at back under construction; 2010: lot still vacant but no new building, building at back finished/
49th Street
NE — 2006: none; 2010: storefront to the left of Discount Wines & Liquors vacant
SE — 2006: sidewalk work; 2010: building to right of Deli either new or big renovation job, replaced Rincon Music, "for rent" sign on it
SW — 2006: construction fence, crane; 2010: fence repainted, lot still vacant, crane(s) gone
NW — 2006: none; 2010: scafffolding up towards left
50th Street
NE — 2006: none; 2010: no change
SE — 2006: none; workmen; 2010: Ramses Deli new tenant or just new awning/signage?
SW — 2006: none; 2010: mural wall on 50th
NW — 2006: none; 2010: scaffolding up on left, concrete ramp wall has stone facing now
51st Street
NE — 2006: none; 2010: Mariachi Mexico Restaurant now Heng Thai Bistro
SE — 2006: xxxxx; 2010: scaffolding still there
SW — 2006: none; 2010: lower floor façade resurfaces, also stone facing on wall
NW — 2006: none; 2010: renovation finished, new tenant is Ristorante Il Melograno
52nd Street
NE — 2006: none; 2010: store closed, mural walls painted over, store for rent, blue building in back repainted beige
SE — 2006: none; 2010: 10th Ave Diner now City Light Diner (name change or new owner?)
SW — 2006: none; 2010: no change
NW — 2006: none; 2010: window frames repainted — new restaurant tenant?
53rd Street
NE — 2006: scaffolding; 2010: scaffolding gone, former tenant appears to be gone too, new scaffolding at right, new (?) façade beyond that
SE — 2006: none; 2010: blue building repainted beige
SW — 2006: construction, crane, blue fencing, etc; 2010: new building finished
NW — 2006: scaffolding; 2010: scaffolding gone
54th Street
NE — 2006: none; 2010: Studio Coffee House now 10th Ave Wines & Liquors, street work sign at far right
SE — 2006: none; 2010: new building replaces old, scaffolding still up, street work too
SW — 2006: scaffolding; 2010: scaffolding gone
NW — 2006: none (but building seems new); 2010: no change
55th Street
NE — 2006: none; 2010: no change
SE — 2006: none; 2010: Mobile Audio closed, signage down
SW — 2006: none; 2010: new awning, signage for 10th Avenue Gourmet Deli
NW — 2006: none (but building seems new); 2010: no change (or is B&N a new partnership with John Jay?)
56th Street
NE — 2006: Caterers closed, storefront vacant; 2010: new tenant is Hanci Turkish Cuisine
SE — 2006: none; workmen; 2010: no change
SW — 2006: none; 2010: no change
NW — 2006: none; 2010: no change
57th Street
NE — 2006: none; 2010: scaffolding, Food Village gone, Chase, Duane Reade instead (or did Food Village just contract towards left?)
SE — 2006: none; 2010: no change
SW — 2006: scaffolding; 2010: scaffolding down
NW — 2006: none; 2010: Jake's Saloon repainted
SUMMARY
In 2006, 19 out of 60 corners (32%) showed signs of change. In 2010, compared with 2006, 44 corners (73%) show actual changes, many of them major (new buildings up, old buildings gone).